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Article

Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase.

Biochemistry - 15 Nov 2016

Levsh Olesya, Chiang Ying-Chih, Tung Chun Fai, Noel Joseph P, Wang Yi, Weng Jing-Ke

Abstract excerpt

Hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyltransferase (HCT) is an essential acyltransferase that mediates flux through plant phenylpropanoid metabolism by catalyzing a reaction between p-coumaroyl-CoA and shikimate, yet it also exhibits broad substrate permissiveness in vitro. How do enzymes like HCT avoid functional derailment by cellular metabolites that qualify as non-native substrates? Here, we combine...

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Identifiers

PMID: 27805809
DOI: 10.1021/acs.biochem.6b00887
PMCID: PMC6276119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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