Article
Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients.
Blood - 29 Dec 2016
Fucikova Jitka, Truxova Iva, Hensler Michal, Becht Etienne, Kasikova Lenka, Moserova Irena, Vosahlikova Sarka, Klouckova Jana, Church Sarah E, Cremer Isabelle, Kepp Oliver, Kroemer Guido, Galluzzi Lorenzo, Salek Cyril, Spisek Radek
Abstract excerpt
Cancer cell death can be perceived as immunogenic by the host only when malignant cells emit immunostimulatory signals (so-called "damage-associated molecular patterns," DAMPs), as they die in the context of failing adaptive responses to stress. Accumulating preclinical and clinical evidence indicates that the capacity of immunogenic cell death to (re-)activate an anticancer immune response is key to the success...
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