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Article

Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

McClure Richard, Ong Henry, Janve Vaibhab, Barton Shawn, Zhu Meiying, Li Bo, Dawes Mary, Jerome W Gray, Anderson Adam, Massion Pierre, Gore John C, Pham Wellington

Abstract excerpt

We report a novel approach for the delivery of curcumin to the brain via inhalation of the aerosol for the potential treatment of Alzheimer's disease. The percentage of plaque fraction in the subiculum and hippocampus reduced significantly when young 5XFAD mice were treated with inhalable curcumin over an extended period of time compared to age-matched nontreated counterparts. Further, treated animals...

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Source

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Identifiers

PMID: 27802223
DOI: 10.3233/JAD-160289
PMCID: PMC5848215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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