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Article

Bip enhanced the association of GSK-3β with tau during ER stress both in vivo and in vitro.

Journal of Alzheimer's disease : JAD - 1 Jan 2012

Liu Zan-Chao, Fu Zheng-Qi, Song Jie, Zhang Jia-Yu, Wei Yu-Ping, Chu Jiang, Han Li, Qu Na, Wang Jian-Zhi, Tian Qing

Abstract excerpt

Hyperphosphorylated tau is the major component of intracellular neurofibrillary tangles, which is positively correlated with the cognitive decline in Alzheimer's disease (AD). The upstream factors leading to tau hyperphosphorylation are still not fully understood. Endoplasmic reticulum (ER) stress has been indicated in AD pathogenesis and the increased level of binding immunoglobulin protein (Bip), an important...

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PMID: 22460328
DOI: 10.3233/JAD-2012-111898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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