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Article

Novel loss‐of‐function mutation in MCM8 causes premature ovarian insufficiency

11 Feb 2020

Abstract excerpt

BACKGROUND: Premature ovarian insufficiency (POI) is one major cause of female infertility, minichromosome maintenance complex component 8 (MCM8) has been reported to be responsible for POI. METHODS: Whole-exome sequencing was performed to identify the genetic variants of women with POI. Sanger sequencing was used to validate the variants in all the family members. Various bioinformatic software was used for the...

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PMID: 32048466
DOI: 10.1002/mgg3.1165

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