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Article

Investigation of an MCM8 gene variant in women with premature ovarian insufficiency.

Einstein (Sao Paulo, Brazil) - 1 Jan 2024

Rabello Beatriz Xavier de Camargo, Rocha Laura Alves da, Barbosa Caio Parente, Bianco Bianca, Christofolini Denise Maria

Abstract excerpt

INTRODUCTION: The MCM8 gene is involved in the homologous recombination and repair of double-stranded DNA breaks. It maintains the meiotic process continuously. If the MCM8-9 helicase does not function, the accumulation of DNA breaks can result in cell death. Studies have reported MCM8 gene suppression with primary ovarian insufficiency. In the present study, a variant of the MCM8 gene was investigated in women...

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Identifiers

PMID: 39607112
DOI: 10.31744/einstein_journal/2024AO0712
PMCID: PMC11634354

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