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Article

B-cell activation with CD40L or CpG measures the function of B-cell subsets and identifies specific defects in immunodeficient patients.

European journal of immunology - 1 Jan 2017

Marasco Emiliano, Farroni Chiara, Cascioli Simona, Marcellini Valentina, Scarsella Marco, Giorda Ezio, Piano Mortari Eva, Leonardi Lucia, Scarselli Alessia, Valentini Diletta, Cancrini Caterina, Duse Marzia, Grimsholm Ola, Carsetti Rita

Abstract excerpt

Around 65% of primary immunodeficiencies are antibody deficiencies. Functional tests are useful tools to study B-cell functions in vitro. However, no accepted guidelines for performing and evaluating functional tests have been issued yet. Here, we report our experience on the study of B-cell functions in infancy and throughout childhood. We show that T-independent stimulation with CpG measures proliferation and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27800605
DOI: 10.1002/eji.201646574

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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