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Article

Interleukin 10 and transforming growth factor beta cooperate to induce anti-CD40-activated naive human B cells to secrete immunoglobulin A.

The Journal of experimental medicine - 1 Mar 1992

Defrance T, Vanbervliet B, Brière F, Durand I, Rousset F, Banchereau J

Abstract excerpt

In the present report, we have investigated the in vitro differentiation of surface(s) sIgD+ and sIgD- human B cells into Ig-secreting cells in response to various stimuli. sIgD+ B cells homogeneously expressed some of the antigens identifying mantle zone B cells, but lacked expression of germinal center markers, thus confirming that the B cell populations positively selected on the basis of sIgD expression were...

Topics

Antibody-Producing Cells
Antigens, CD
Antigens, Differentiation, B-Lymphocyte
B-Lymphocytes
CD40 Antigens
Humans
Immunoglobulin A
Immunoglobulin A, Secretory
Immunoglobulin D
Immunoglobulin Isotypes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Interleukin-10

Lymphocyte Activation

Phenotype

Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 1371300
DOI: 10.1084/jem.175.3.671
PMCID: PMC2119142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1371300-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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