Article

Alteration of serum leptin and LEP/LEPR promoter methylation in Prader-Willi syndrome

2021-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Prader-Willi syndrome (PWS) is a rare neurodevelopmental disorder based on a loss of paternally expressed but maternally imprinted genes in chromosome region 15q11-13. During child development, PWS usually results in insatiable appetite with subsequent obesity representing the major mortality factor. The neurobiological basis of PWS-typical hyperphagia has remained poorly understood. Many PWS-typ...

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Literature Corpus work: fce2fa45-3dd2-5af8-891e-a66e688a2cff
DOI: 10.1101/2021.12.15.21267839

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