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Sequence-specific DNA alkylation targeting for Kras codon 13 mutation by pyrrole-imidazole polyamide seco-CBI conjugates.

Chemistry (Weinheim an der Bergstrasse, Germany) - 27 Jan 2014

Taylor Rhys Dylan, Asamitsu Sefan, Takenaka Tomohiro, Yamamoto Makoto, Hashiya Kaori, Kawamoto Yusuke, Bando Toshikazu, Nagase Hiroki, Sugiyama Hiroshi

Abstract excerpt

Hairpin N-methylpyrrole-N-methylimidazole polyamide seco-CBI conjugates 2-6 were designed for synthesis by Fmoc solid-phase synthesis, and their DNA-alkylating activities against the Kras codon 13 mutation were compared by high-resolution denaturing gel electrophoresis with 225 base pair (bp) DNA fragments. Conjugate 5 had high reactivity towards the Kras codon 13 mutation site, with alkylation occurring at the A...

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PMID: 24382626
DOI: 10.1002/chem.201303295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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