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Article

Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides.

PloS one - 1 Jan 2021

Ota Yoko, Yoda Hiroyuki, Inoue Takahiro, Watanabe Takayoshi, Shinozaki Yoshinao, Takatori Atsushi, Nagase Hiroki

Abstract excerpt

Anaplastic lymphoma kinase (ALK) aberration is related to high-risk neuroblastomas and is an important therapeutic target. As acquired resistance to ALK tyrosine kinase inhibitors is inevitable, novel anti-ALK drug development is necessary in order to overcome potential drug resistance against ATP-competitive kinase inhibitors. In this study, to overcome ALK inhibitor resistance, we examined the growth inhibition...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34591871
DOI: 10.1371/journal.pone.0257718
PMCID: PMC8483358

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