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ICOS-Ligand Triggering Impairs Osteoclast Differentiation and Function In Vitro and In Vivo

20 Oct 2016

Abstract excerpt

Abstract Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production and resorption, which are crucial in bone homeostasis. OC hyperactivation plays a role in the exaggerated bone resorption of diseases such as osteoporosis, rheumatoid arthritis, and osteolytic tumor metastases. This work stems from the finding that OCs can express B7h (ICOS-Ligand), which is the ligand of the ICOS T cell...

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PMID: 27798154
DOI: 10.4049/jimmunol.1600424

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