Article
CD46 (membrane cofactor protein of complement, measles virus receptor): structural and functional divergence among species (review).
International journal of molecular medicine - 1 May 1998
Seya T, Nomura M, Murakami Y, Begum N A, Matsumoto M, Nagasawa S
Abstract excerpt
Human CD46 was identified as a complement regulator and was later shown to be a measles virus receptor. The ubiquitous distribution profile of CD46 accounted for systemic measles infection and general protection of host tissue/organs from autologous complement. A similar ubiquitous distribution was observed for swine and simian CD46 homologues based upon subsequent cDNA cloning and Northern analysis, reinforcing...
Topics
- Amino Acid Sequence
- Animals
- Antigens, CD
- Complement Activation
- Complement Inactivator Proteins
- Conserved Sequence
- Genetic Variation
- Humans
- Measles virus
- Membrane Cofactor Protein
- Membrane Glycoproteins
- Molecular Sequence Data
- Protein Isoforms