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DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme

28 Oct 2016

Abstract excerpt

Abstract Cancer cells can resist the effects of DNA-damaging therapeutic agents via utilization of DNA repair pathways, suggesting that DNA repair capacity (DRC) measurements in cancer cells could be used to identify patients most likely to respond to treatment. However, the limitations of available technologies have so far precluded adoption of this approach in the clinic. We recently developed...

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PMID: 27793847
DOI: 10.1158/0008-5472.can-16-1151

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