Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

doi:10.1053/j.gastro.2012.09.061

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Article

Inactivation of Patched1 in mice leads to development of gastrointestinal stromal-like tumors that express Pdgfrα but not kit.

Gastroenterology - 1 Jan 2013

Pelczar Penelope, Zibat Arne, van Dop Willemijn A, Heijmans Jarom, Bleckmann Annalen, Gruber Wolfgang, Nitzki Frauke, Uhmann Anja, Guijarro Maria V, Hernando Eva, Dittmann Kai, Wienands Jürgen, Dressel Ralf, Wojnowski Leszek, Binder Claudia, Taguchi Takahiro, Beissbarth Tim, Hogendoorn Pancras C W, Antonescu Cristina R, Rubin Brian P, Schulz-Schaeffer Walter, Aberger Fritz, van den Brink Gijs R, Hahn Heidi

Abstract excerpt

BACKGROUND & AIMS: A fraction of gastrointestinal stromal tumor (GIST) cells overexpress the platelet-derived growth factor receptor (PDGFR)A, although most overexpress KIT. It is not known if this is because these receptor tyrosine kinases have complementary oncogenic potential, or because of heterogeneity in the cellular origin of GIST. Little also is known about why Hedgehog (HH) signaling is activated in some...

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Identifiers

PMID: 23041331
DOI: 10.1053/j.gastro.2012.09.061
PMCID: PMC4231777

Genes

KIT
PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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