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Article

Gene expression patterns of hemizygous and heterozygous KIT mutations suggest distinct oncogenic pathways: a study in NIH3T3 cell lines and GIST samples.

PloS one - 1 Jan 2013

Bachet Jean-Baptiste, Tabone-Eglinger Séverine, Dessaux Sophie, Besse Anthony, Brahimi-Adouane Sabrina, Emile Jean-François, Blay Jean-Yves, Alberti Laurent

Abstract excerpt

OBJECTIVE: Most gain of function mutations of tyrosine kinase receptors in human tumours are hemizygous. Gastrointestinal stromal tumours (GIST) with homozygous mutations have a worse prognosis. We aimed to identify genes differentially regulated by hemizygous and heterozygous KIT mutations. MATERIALS AND METHODS: Expression of 94 genes and 384 miRNA was analysed with low density arrays in five NIH3T3 cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23593401
DOI: 10.1371/journal.pone.0061103
PMCID: PMC3625162

Genes

KIT
ANXA8
FBN1
RGS16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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