Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heritable DNA Methylation in CD4+ Cells among Complex Families Displays Genetic and Non-Genetic Effects.

PloS one - 1 Jan 2016

Day Kenneth, Waite Lindsay L, Alonso Arnald, Irvin Marguerite R, Zhi Degui, Thibeault Krista S, Aslibekyan Stella, Hidalgo Bertha, Borecki Ingrid B, Ordovas Jose M, Arnett Donna K, Tiwari Hemant K, Absher Devin M

Abstract excerpt

DNA methylation at CpG sites is both heritable and influenced by environment, but the relative contributions of each to DNA methylation levels are unclear. We conducted a heritability analysis of CpG methylation in human CD4+ cells across 975 individuals from 163 families in the Genetics of Lipid-lowering Drugs and Diet Network (GOLDN). Based on a broad-sense heritability (H2) value threshold of 0.4, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to CpG Islands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Molecular Sequence Annotation

Share to Pedigree

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 27792787
DOI: 10.1371/journal.pone.0165488
PMCID: PMC5085095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heritable DNA Methylation in CD4+ Cells among Complex Families Displays Genetic and Non-Genetic Effects.PMID 27792787Read ↗

Patterns of methylation heritability in a genome-wide analysis of four brain regions.Semantic proximity Read ↗

Genomic and phenomic insights from an atlas of genetic effects on DNA methylationSemantic proximity Read ↗

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation.Semantic proximity Read ↗

High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction.Semantic proximity Read ↗

Allele-specific methylation occurs at genetic variants associated with complex disease.Semantic proximity Read ↗

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of diseaseSemantic proximity Read ↗

Genetic control of DNA methylation is largely shared across European and East Asian populations.Semantic proximity Read ↗

DNA methylation contributes to natural human variation.Semantic proximity Read ↗

Leveraging DNA methylation quantitative trait loci to characterize the relationship between methylomic variation, gene expression and complex traitsSemantic proximity Read ↗

Genetic impacts on DNA methylation help elucidate regulatory genomic processesSemantic proximity Read ↗

Human panepigenome represents epigenomic diversitySemantic proximity Read ↗

Elucidating the genetic architecture of DNA methylation to identify promising molecular mechanisms of disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.