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"Beyond HER2 overexpression: somatic alterations in HER2 and PI3K genes in HER2-high and HER2-low/TNBC breast cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Jul 2026

Thakur Tamanna, Khare Siddhant, Irriniki Santosh, Laroiya Ishita, Kumar Rajender, Bhattacharyya Shalmoli, Bal Amanjit

Abstract excerpt

BACKGROUND: HER2-overexpressing (3+) breast cancer exhibits distinct clinicopathological characteristics compared to HER2 1+ and 2+ tumors; however, differences in their molecular features remain poorly defined. This study aimed to investigate clinicopathologic and somatic alterations in breast tumors stratified by HER2 status. MATERIALS AND METHODS: Ninety breast cancer patients were stratified by HER2...

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Identifiers

PMID: 41548171
DOI: 10.1007/s12094-025-04193-5

Genes

PIK3CA
ERBB2
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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