Article
The GTPase-activating protein-related domain of neurofibromin interacts with MC1R and regulates pigmentation-mediated signaling in human melanocytes.
Biochemical and biophysical research communications - 1 Jan 2021
Deraredj Nadim Wissem, Hassanaly Shalina, Bénédetti Hélène, Kieda Claudine, Grillon Catherine, Morisset-Lopez Severine
Abstract excerpt
The melanocortin 1 receptor (MC1R) is a G-protein coupled receptor (GPCR) which plays a major role in controlling melanogenesis. A large body of evidence indicates that GPCRs are part of large protein complexes that are critical for their signal transduction properties. Among proteins which may affect MC1R signaling, neurofibromin (Nf1), a GTPase activating protein (GAP) for Ras, is of special interest as it...
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