Article
Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection.
Gut - 1 Feb 2018
Murata Kazumoto, Asano Mai, Matsumoto Akihiro, Sugiyama Masaya, Nishida Nao, Tanaka Eiji, Inoue Taisuke, Sakamoto Minoru, Enomoto Nobuyuki, Shirasaki Takayoshi, Honda Masao, Kaneko Shuichi, Gatanaga Hiroyuki, Oka Shinichi, Kawamura Yuki I, Dohi Taeko, Shuno Yasutaka, Yano Hideaki, Mizokami Masashi
Abstract excerpt
OBJECTIVE: The clinical significance of polymorphisms in the interleukin-28B gene encoding interferon (IFN)-λ3, which has antiviral effects, is known in chronic HCV but not in HBV infection. Thus, we measured IFN-λ3 levels in patients with HBV and investigated its clinical significance and association with nucleos(t)ide (NUC) analogue administration. DESIGN: Serum IFN-λ3 level was measured in 254 patients with...
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