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Article

Effect of Antiviral Treatment on Hepatitis B Virus Integration and Hepatocyte Clonal Expansion

20 May 2022

Abstract excerpt

BACKGROUND: This study investigated the effect of nucleos(t)ide analogue (NUC) treatment on hepatitis B virus (HBV) DNA integration and hepatocyte clonal expansion, both of which are implicated in hepatocellular carcinoma (HCC) in chronic hepatitis B. METHODS: Twenty-eight patients receiving NUCs (11 lamivudine, 7 telbivudine, 10 entecavir) were included. All had liver biopsies at baseline and year 1, and 7 had a...

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PMID: 35594553
DOI: 10.1093/cid/ciac383

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