Article
Factors influencing the response to interferon therapy in chronic hepatitis C. Studies on viral genotype and induction of 2',5'-oligoadenylate synthetase in the liver and peripheral blood cells.
Scandinavian journal of gastroenterology - 1 Jun 1996
Grandér D, Hultcrantz R, Weiland O, Xu B, Sangfelt O, Björklund A C, Befrits R, Björkholm M, Gruber A, Kinnman N, Reichard O, Widell A, Einhorn S
Abstract excerpt
BACKGROUND: The mechanism behind the antiviral action of interferon (IFN) therapy in chronic hepatitis C virus (HCV) infection is not well understood, and, furthermore, few factors have been shown to be good predictors of a favourable response to IFN treatment in chronic HCV infection. METHODS: Freshly explanted liver cells and peripheral blood mononuclear cells (PBMC) from 80 patients with chronic HCV infection...
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