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Article

Determination of clinically relevant cutoffs for HIV-1 phenotypic resistance estimates through a combined analysis of clinical trial and cohort data.

Journal of acquired immune deficiency syndromes (1999) - 1 May 2008

Winters Bart, Montaner Julio, Harrigan P Richard, Gazzard Brian, Pozniak Anton, Miller Michael D, Emery Sean, van Leth Frank, Robinson Patrick, Baxter John D, Perez-Elias Marie, Castor Delivette, Hammer Scott, Rinehart Alex, Vermeiren Hans, Van Craenenbroeck Elke, Bacheler Lee

Abstract excerpt

BACKGROUND: Clinically relevant cutoffs are needed for the interpretation of HIV-1 phenotypic resistance estimates as predicted by "virtual" phenotype HIV resistance analysis. METHODS: Using a clinical data set containing 2596 treatment change episodes in 2217 patients in 8 clinical trials and 2 population-based cohorts, drug-specific linear regression models were developed to describe the relation between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18360290
DOI: 10.1097/QAI.0b013e31816d9bf4

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