Article
TM6SF2 E167K variant predicts severe liver fibrosis for human immunodeficiency/hepatitis C virus co-infected patients, and severe steatosis only for a non-3 hepatitis C virus genotype.
World journal of gastroenterology - 14 Oct 2016
Sagnelli Caterina, Merli Marco, Uberti-Foppa Caterina, Hasson Hamid, Grandone Anna, Cirillo Grazia, Salpietro Stefania, Minichini Carmine, Starace Mario, Messina Emanuela, Morelli Patrizia, Miraglia Del Giudice Emanuele, Lazzarin Adriano, Coppola Nicola, Sagnelli Evangelista
Abstract excerpt
AIM: To evaluate the impact of the Glu167Lys (E167K) transmembrane 6 superfamily member 2 (TM6SF2) variant on the biochemical and morphologic expression of liver lesions in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) co-infected patients. METHODS: The study comprised 167 consecutive patients with HIV/HCV coinfection and biopsy-proven chronic hepatitis. A pathologist graded liver fibrosis and...
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