Article
TM6SF2 E167K variant is associated with severe steatosis in chronic hepatitis C, regardless of PNPLA3 polymorphism.
Liver international : official journal of the International Association for the Study of the Liver - 1 Aug 2015
Coppola Nicola, Rosa Zampino, Cirillo Grazia, Stanzione Maria, Macera Margherita, Boemio Adriana, Grandone Anna, Pisaturo Mariantonietta, Marrone Aldo, Adinolfi Luigi E, Sagnelli Evangelista, Miraglia del Giudice Emanuele
Abstract excerpt
BACKGROUND & AIMS: A common non-synonymous polymorphism, E167K, in transmembrane six superfamily member 2 (TM6SF2) gene has been recently associated with an increased hepatic triglyceride content, dyslipidemia and liver fibrosis in NAFLD patients. We investigated possible associations between the TM6SF2 variants and liver lesions in chronic hepatitis C. PATIENTS AND METHODS: 148 consecutive patients with biopsy...
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