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Article

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models.

PloS one - 1 Jan 2015

Rajpal Deepak K, Klein Jean-Louis, Mayhew David, Boucheron Joyce, Spivak Aaron T, Kumar Vinod, Ingraham Karen, Paulik Mark, Chen Lihong, Van Horn Stephanie, Thomas Elizabeth, Sathe Ganesh, Livi George P, Holmes David J, Brown James R

Abstract excerpt

The gastrointestinal tract microbiome has been suggested as a potential therapeutic target for metabolic diseases such as obesity and Type 2 diabetes mellitus (T2DM). However, the relationship between changes in microbial communities and metabolic disease-phenotypes are still poorly understood. In this study, we used antibiotics with markedly different antibacterial spectra to modulate the gut microbiome in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26709835
DOI: 10.1371/journal.pone.0145499
PMCID: PMC4692534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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