Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet.

Genome medicine - 27 Apr 2016

Mahana Douglas, Trent Chad M, Kurtz Zachary D, Bokulich Nicholas A, Battaglia Thomas, Chung Jennifer, Müller Christian L, Li Huilin, Bonneau Richard A, Blaser Martin J

Abstract excerpt

BACKGROUND: Obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD) are serious health concerns, especially in Western populations. Antibiotic exposure and high-fat diet (HFD) are important and modifiable factors that may contribute to these diseases. METHODS: To investigate the relationship of antibiotic exposure with microbiome perturbations in a murine model of growth promotion, C57BL/6 mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adiposity
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Microbiome

Share to Hormones

Share to Liver Diseases

Share to Metagenome

Share to Metagenomics

Share to Non-alcoholic Fatty Liver Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 27124954
DOI: 10.1186/s13073-016-0297-9
PMCID: PMC4847194

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antibiotic perturbation of the murine gut microbiome enhances the adiposity, insulin resistance, and liver disease associated with high-fat diet.PMID 27124954Read ↗

Antibiotic-mediated gut microbiome perturbation accelerates development of type 1 diabetes in mice.Semantic proximity Read ↗

Modulation of Gut Microbiota and Antibiotic Resistance Genes by Heat-Killed Enterococcus faecalis EF-2001 in High-Fat Diet-Induced Obesity Mice: A Shotgun Metagenomics StudySemantic proximity Read ↗

The short term High Fat Diet sparks gut microbiota associated metabolic syndrome pathogenesis and impact of Amoxicillin intervention in miceSemantic proximity Read ↗

Selective Spectrum Antibiotic Modulation of the Gut Microbiome in Obesity and Diabetes Rodent Models.Semantic proximity Read ↗

Microbial and Transcriptomic Profiling Reveals Diet-Related Alterations of Metabolism in Metabolic Disordered MiceSemantic proximity Read ↗

Antibiotic-Induced Alterations in Gut Microbiota Are Associated with Changes in Glucose Metabolism in Healthy MiceSemantic proximity Read ↗

Integrative Longitudinal Analysis of Metabolic Phenotype and Microbiota Changes During the Development of Obesity.Semantic proximity Read ↗

Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatmentSemantic proximity Read ↗

Alteration of gut microbiota affects expression of adiponectin and resistin through modifying DNA methylation in high-fat diet-induced obese miceSemantic proximity Read ↗

The impact of multigenerational high-fat diet feeding on the gut microbiome and host metabolismSemantic proximity Read ↗

High-fat and low-fiber diet elevates the gut resistome: a comparative metagenomic studySemantic proximity Read ↗

Gut microbiota phospholipids regulate intestinal gene expression and can counteract the effects of antibiotic treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.