Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms.

doi:10.1158/0008-5472.CAN-16-1699

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Article

Pancreatic Cancer Risk Associated with Prediagnostic Plasma Levels of Leptin and Leptin Receptor Genetic Polymorphisms.

Cancer research - 15 Dec 2016

Babic Ana, Bao Ying, Qian Zhi Rong, Yuan Chen, Giovannucci Edward L, Aschard Hugues, Kraft Peter, Amundadottir Laufey T, Stolzenberg-Solomon Rachael, Morales-Oyarvide Vicente, Ng Kimmie, Stampfer Meir J, Ogino Shuji, Buring Julie E, Sesso Howard D, Gaziano John Michael, Rifai Nader, Pollak Michael N, Anderson Matthew L, Cochrane Barbara B, Luo Juhua, Manson JoAnn E, Fuchs Charles S, Wolpin Brian M

Abstract excerpt

Leptin is an adipokine involved in regulating energy balance, which has been identified as a potential biologic link in the development of obesity-associated cancers, such as pancreatic cancer. In this prospective, nested case-control study of 470 cases and 1,094 controls from five U.S. cohorts, we used conditional logistic regression to evaluate pancreatic cancer risk by prediagnostic plasma leptin, adjusting...

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PMID: 27780823
DOI: 10.1158/0008-5472.CAN-16-1699
PMCID: PMC5181854

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LEPR

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