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Article

Evaluating the causal role of LEPR signaling in 16 cancers: A drug-target Mendelian randomization study.

Medicine - 10 Apr 2026

Chen Jihao, Yang Xuefei, Huang Ting, Zhou Heran

Abstract excerpt

The leptin receptor (LEPR) serves as a central regulator of energy balance and metabolic homeostasis, with growing interest in its pleiotropic roles in cancer. However, existing evidence on its oncogenic function remains ambiguous, with studies reporting both tumor-promoting and tumor-suppressive effects across different contexts. This duality complicates the interpretation of LEPR's precise role in...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41961674
DOI: 10.1097/MD.0000000000048181

Genes

LEPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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