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Article

cIAPs promote the proteasomal degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis.

Biochemical and biophysical research communications - 18 Nov 2016

Choi Jin Sun, Kim Kidae, Lee Do Hee, Cho Sayeon, Ha Jae Du, Park Byoung Chul, Kim Sunhong, Park Sung Goo, Kim Jeong-Hoon

Abstract excerpt

Although the ubiquitin-proteasome system is believed to play an important role in the pathogenesis of familial amyotrophic lateral sclerosis (FALS), caused by mutations in Cu/Zn-superoxide dismutase 1 (SOD1), the mechanism of how mutant SOD1 protein is regulated in cells is still poorly understood. Here we have demonstrated that cellular inhibitor of apoptosis proteins (cIAPs) are specifically associated with...

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Source

Identifiers

PMID: 27773815
DOI: 10.1016/j.bbrc.2016.10.065

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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