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Article

Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.

Molecular biology of the cell - 1 Nov 2009

Yonashiro Ryo, Sugiura Ayumu, Miyachi Misako, Fukuda Toshifumi, Matsushita Nobuko, Inatome Ryoko, Ogata Yoshinobu, Suzuki Takehiro, Dohmae Naoshi, Yanagi Shigeru

Abstract excerpt

We have previously identified a novel mitochondrial ubiquitin ligase, MITOL, which is localized in the mitochondrial outer membrane and is involved in the control of mitochondrial dynamics. In this study, we examined whether MITOL eliminates misfolded proteins localized to mitochondria. Mutant superoxide dismutase1 (mSOD1), one of misfolded proteins, has been shown to localize in mitochondria and induce...

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Identifiers

PMID: 19741096
DOI: 10.1091/mbc.e09-02-0112
PMCID: PMC2770940

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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