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Article

Does Sequence Conservation Provide Evidence for Biological Function?

Trends in microbiology - 1 Jan 2017

Omer Seila, Harlow Timothy J, Gogarten Johann Peter

Abstract excerpt

Finding a signature of purifying selection in a gene is usually interpreted as evidence for the gene providing a function that is targeted by natural selection. This opinion offers a very different hypothesis: purifying selection may be due to removing harmful mutations from the population, that is, the gene and its encoded protein become harmful after a mutation occurred, possibly because the mutated protein...

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Identifiers

PMID: 27773523
DOI: 10.1016/j.tim.2016.09.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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