Article
Effective use of sequence correlation and conservation in fold recognition.
Journal of molecular biology - 12 Nov 1999
Olmea O, Rost B, Valencia A
Abstract excerpt
Protein families are a rich source of information; sequence conservation and sequence correlation are two of the main properties that can be derived from the analysis of multiple sequence alignments. Sequence conservation is related to the direct evolutionary pressure to retain the chemical characteristics of some positions in order to maintain a given function. Sequence correlation is attributed to the small...
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