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Article

Why is the correlation between gene importance and gene evolutionary rate so weak?

PLoS genetics - 1 Jan 2009

Wang Zhi, Zhang Jianzhi

Abstract excerpt

One of the few commonly believed principles of molecular evolution is that functionally more important genes (or DNA sequences) evolve more slowly than less important ones. This principle is widely used by molecular biologists in daily practice. However, recent genomic analysis of a diverse array of organisms found only weak, negative correlations between the evolutionary rate of a gene and its functional...

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PMID: 19132081
DOI: 10.1371/journal.pgen.1000329
PMCID: PMC2605560

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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