Article
A cancer-associated mutation in atypical protein kinase Cι occurs in a substrate-specific recruitment motif.
Science signaling - 17 Sept 2013
Linch Mark, Sanz-Garcia Marta, Soriano Erika, Zhang Yixiao, Riou Philippe, Rosse Carine, Cameron Angus, Knowles Phillip, Purkiss Andrew, Kjaer Svend, McDonald Neil Q, Parker Peter J
Abstract excerpt
Atypical protein kinase Cι (PKCι) has roles in cell growth, cellular polarity, and migration, and its abundance is frequently increased in cancer. We identified a protein interaction surface containing a dibasic motif (RIPR) that bound a distinct subset of PKCι substrates including lethal giant larvae 2 (LLGL2) and myosin X, but not other substrates such as Par3. Further characterization demonstrated that Arg471...
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