Article
Elevation of n-3/n-6 PUFAs ratio suppresses mTORC1 and prevents colorectal carcinogenesis associated with APC mutation.
Oncotarget - 22 Nov 2016
Liu Miao, Zhou Ling, Zhang Baiyu, He Minhong, Dong Xiaoying, Lin Xiaojun, Jia Chunhong, Bai Xiaochun, Dai Yifan, Su Yongchun, Zou Zhipeng, Zheng Hang
Abstract excerpt
Although epidemiological and preclinical studies have shown the preventative effect of n-3 polyunsaturated fatty acids (PUFAs) on colorectal cancer (CRC), the underlying molecular mechanisms are not clear. In this study, we revealed that elevation of n-3/n-6 PUFAs ratio suppress the mechanistic target of rapamycin complex 1 (mTORC1) and prevent colorectal tumorigenesis. The transgenic expression of fat-1, a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.