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Article

An Explorative Study on Monocyte Reprogramming in the Context of Periodontitis In Vitro and In Vivo.

Frontiers in immunology - 1 Jan 2021

Noz Marlies P, Plachokova Adelina S, Smeets Esther M M, Aarntzen Erik H J G, Bekkering Siroon, Vart Prya, Joosten Leo A B, Netea Mihai G, Riksen Niels P

Abstract excerpt

Aims: Periodontitis is an independent risk factor for cardiovascular disease, but the mechanistic link is not fully understood. In atherosclerotic cardiovascular disease, monocytes can adopt a persistent hyperresponsive phenotype, termed trained immunity. We hypothesized that periodontitis-associated bacteria can induce trained immunity in monocytes, which subsequently accelerate atherosclerosis development....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34484192
DOI: 10.3389/fimmu.2021.695227
PMCID: PMC8414567

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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