Article
Genome-Wide Meta-Analysis of Sciatica in Finnish Population.
PloS one - 1 Jan 2016
Lemmelä Susanna, Solovieva Svetlana, Shiri Rahman, Benner Christian, Heliövaara Markku, Kettunen Johannes, Anttila Verneri, Ripatti Samuli, Perola Markus, Seppälä Ilkka, Juonala Markus, Kähönen Mika, Salomaa Veikko, Viikari Jorma, Raitakari Olli T, Lehtimäki Terho, Palotie Aarno, Viikari-Juntura Eira, Husgafvel-Pursiainen Kirsti
Abstract excerpt
Sciatica or the sciatic syndrome is a common and often disabling low back disorder in the working-age population. It has a relatively high heritability but poorly understood molecular mechanisms. The Finnish population is a genetic isolate where small founder population and bottleneck events have led to enrichment of certain rare and low frequency variants. We performed here the first genome-wide association...
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