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Article

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System.

The Journal of pharmacology and experimental therapeutics - 1 Jan 2017

Tsamandouras N, Kostrzewski T, Stokes C L, Griffith L G, Hughes D J, Cirit M

Abstract excerpt

In this work, we first describe the population variability in hepatic drug metabolism using cryopreserved hepatocytes from five different donors cultured in a perfused three-dimensional human liver microphysiological system, and then show how the resulting data can be integrated with a modeling and simulation framework to accomplish in vitro-in vivo translation. For each donor, metabolic depletion profiles of six...

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Identifiers

PMID: 27760784
DOI: 10.1124/jpet.116.237495
PMCID: PMC5193075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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