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Article

Drug metabolism by cultured human hepatocytes: how far are we from the in vivo reality?

Alternatives to laboratory animals : ATLA - 1 Jun 2004

Ponsoda Xavier, Donato M Teresa, Perez-Cataldo Gabriela, Gómez-Lechón Maria José, Castell José V

Abstract excerpt

The investigation of metabolism is an important milestone in the course of drug development. Drug metabolism is a determinant of drug pharmacokinetics variability in human beings. Fundamental to this are phenotypic differences, as well as genotypic differences, in the expression of the enzymes involved in drug metabolism. Genotypic variability is easy to identify by means of polymerase chain reaction-based or DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 15601238
DOI: 10.1177/026119290403200207

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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