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Article

ATP13A2 regulates mitochondrial bioenergetics through macroautophagy.

Neurobiology of disease - 1 Mar 2012

Gusdon Aaron M, Zhu Jianhui, Van Houten Bennett, Chu Charleen T

Abstract excerpt

Mitochondrial dysfunction and autophagy are centrally implicated in Parkinson's disease (PD). Mutations in ATP13A2, which encodes a lysosomal P-type ATPase of unknown function, cause a rare, autosomal recessive parkinsonian syndrome. Lysosomes are essential for autophagy, and autophagic clearance of dysfunctional mitochondria represents an important element of mitochondrial quality control. In this study, we...

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Identifiers

PMID: 22198378
DOI: 10.1016/j.nbd.2011.12.015
PMCID: PMC3291101

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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