Article
CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
The American journal of pathology - 1 Dec 2016
Bae Jun Sang, Park See-Hyoung, Jamiyandorj Urangoo, Kim Kyoung Min, Noh Sang Jae, Kim Jung Ryul, Park Hye Jeong, Kwon Keun Sang, Jung Sung Hoo, Park Ho Sung, Park Byung-Hyun, Lee Ho, Moon Woo Sung, Sylvester Karl G, Jang Kyu Yun
Abstract excerpt
Recently, the roles of sirtuins (SIRTs) in tumorigenesis have been of interest to oncologists, and protein kinase CK2 α1 (CSNK2A1) has been shown to be involved in tumorigenesis by phosphorylating various proteins, including SIRT1. Therefore, we evaluated the roles of CSNK2A1, SIRT6, and phosphorylated SIRT6 and their relationships in breast carcinoma. Nuclear expression of CSNK2A1 and SIRT6 predicted shorter...
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