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SIRT3‐dependent delactylation of cyclin E2 prevents hepatocellular carcinoma growth

10 Mar 2023

Abstract excerpt

-dependent deacetylase SIRT3, which can also catalyze removal of the lactyl moiety from lysine, is expressed at low levels in hepatocellular carcinoma (HCC) and has been suggested to be an HCC tumor suppressor. Here we report that SIRT3 can delactylate non-histone proteins and suppress HCC development. Using SILAC-based quantitative proteomics, we identify cyclin E2 (CCNE2) as one of the lactylated substrates of...

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PMID: 36896611
DOI: 10.15252/embr.202256052

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