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Article

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

6 Aug 2015

Abstract excerpt

Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. Here we show region-specific variation in MAT adipocyte development, regulation, size, lipid composition, gene expression and genetic determinants. Early MAT formation in mice is conserved, whereas later development is strain dependent. Proximal, but not distal tibial, MAT is lost with 21-day cold exposure. Rat...

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PMID: 26245716
DOI: 10.1038/ncomms8808

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