Article
Identification of novel variants associated with warfarin stable dosage by use of a two-stage extreme phenotype strategy.
Journal of thrombosis and haemostasis : JTH - 1 Jan 2017
Luo Z, Li X, Zhu M, Tang J, Li Z, Zhou X, Song G, Liu Z, Zhou H, Zhang W
Abstract excerpt
Essentials Required warfarin doses for mechanical heart valves vary greatly. A two-stage extreme phenotype design was used to identify novel warfarin dose associated mutation. We identified a group of variants significantly associated with extreme warfarin dose. Four novel identified mutations account for 2.2% of warfarin dose discrepancies. SUMMARY: Background The variation among patients in warfarin response...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.