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Maternal Folate Status and the BHMT c.716G>A Polymorphism Affect the Betaine Dimethylglycine Pathway during Pregnancy.

Nutrients - 9 Oct 2016

Colomina Jose M, Cavallé-Busquets Pere, Fernàndez-Roig Sílvia, Solé-Navais Pol, Fernandez-Ballart Joan D, Ballesteros Mónica, Ueland Per M, Meyer Klaus, Murphy Michelle M

Abstract excerpt

The effect of the betaine: homocysteine methyltransferase BHMT c.716G>A (G: guanosine; A: adenosine) single nucleotide polymorphism (SNP) on the BHMT pathway is unknown during pregnancy. We hypothesised that it impairs betaine to dimethylglycine conversion and that folate status modifies its effect. We studied 612 women from the Reus Tarragona Birth Cohort from ≤12 gestational weeks (GW) throughout pregnancy. The...

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Identifiers

PMID: 27735840
DOI: 10.3390/nu8100621
PMCID: PMC5084009

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BHMT

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