Article
Impact of high-dose folic acid supplementation in pregnancy on biomarkers of folate status and 1-carbon metabolism: An ancillary study of the Folic Acid Clinical Trial (FACT).
The American journal of clinical nutrition - 8 May 2021
Murphy Malia S Q, Muldoon Katherine A, Sheyholislami Hauna, Behan Nathalie, Lamers Yvonne, Rybak Natalie, White Ruth Rennicks, Harvey Alysha L J, Gaudet Laura M, Smith Graeme N, Walker Mark C, Wen Shi Wu, MacFarlane Amanda J
Abstract excerpt
BACKGROUND: Periconceptional folic acid (FA) supplementation is recommended to prevent the occurrence of neural tube defects. Currently, most over-the-counter FA supplements in Canada and the United States contain 1 mg FA and some women are prescribed 5 mg FA/d. High-dose FA is hypothesized to impair 1-carbon metabolism. We aimed to determine folate and 1-carbon metabolism biomarkers in pregnant women exposed to...
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