Article
High Epstein-Barr Virus Load and Genomic Diversity Are Associated with Generation of gp350-Specific Neutralizing Antibodies following Acute Infectious Mononucleosis.
Journal of virology - 1 Jan 2017
Weiss Eric R, Alter Galit, Ogembo Javier Gordon, Henderson Jennifer L, Tabak Barbara, Bakiş Yasin, Somasundaran Mohan, Garber Manuel, Selin Liisa, Luzuriaga Katherine
Abstract excerpt
The Epstein-Barr virus (EBV) gp350 glycoprotein interacts with the cellular receptor to mediate viral entry and is thought to be the major target for neutralizing antibodies. To better understand the role of EBV-specific antibodies in the control of viral replication and the evolution of sequence diversity, we measured EBV gp350-specific antibody responses and sequenced the gp350 gene in samples obtained from...
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