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Article

Epstein-Barr virus latent membrane protein 1 genetic variability in peripheral blood B cells and oropharyngeal fluids.

Journal of virology - 1 Apr 2014

Renzette Nicholas, Somasundaran Mohan, Brewster Frank, Coderre James, Weiss Eric R, McManus Margaret, Greenough Thomas, Tabak Barbara, Garber Manuel, Kowalik Timothy F, Luzuriaga Katherine

Abstract excerpt

UNLABELLED: We report the diversity of latent membrane protein 1 (LMP1) gene founder sequences and the level of Epstein-Barr virus (EBV) genome variability over time and across anatomic compartments by using virus genomes amplified directly from oropharyngeal wash specimens and peripheral blood B cells during acute infection and convalescence. The intrahost nucleotide variability of the founder virus was 0.02%...

Topics

B-Lymphocytes
Cluster Analysis
DNA, Viral
Epstein-Barr Virus Infections
Genetic Variation
Herpesvirus 4, Human
Humans
Molecular Sequence Data
Oropharynx
Phylogeny

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, DNA

Time Factors

Viral Matrix Proteins

Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 24429365
DOI: 10.1128/JVI.03378-13
PMCID: PMC3993555

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