Structural basis of Epstein-Barr virus gp350 receptor recognition and neutralization

doi:10.1016/j.celrep.2024.115168

Article

Structural basis of Epstein-Barr virus gp350 receptor recognition and neutralization

1 Jan 2025

Abstract excerpt

Epstein-Barr virus (EBV) is an oncogenic virus associated with multiple lymphoid malignancies and autoimmune diseases. During infection in B cells, EBV uses its major glycoprotein gp350 to recognize the host receptor CR2, initiating viral attachment, a process that has lacked direct structural evidence for decades. In this study, we resolved the structure of the gp350-CR2 complex, elucidated their key...

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